Bromantane

Negative side effects of Bromantane

In a large study on the effects of Bromantane in 728 people with the medical condition asthenia, the drug had the following safety profile:

"Adverse effects were observed only in 3% of patients, the therapy was discontinued in 0.8%. No serious adverse effects were found." [6]

This frequency of negative side effects is very low, and might have been entirely due to the placebo effect or random chance.

The study authors concluded that Bromantane is well-tolerated and safe.

Is Bromantane addictive?

In contrast with many other stimulant drugs, it appears that Bromantane is not addictive. [10]

No withdrawal symptoms occurred during one week after participants stopped using the Bromantane which they had received daily for 28 days.

Should you use Bromantane?

One thing that is certain about the effects of Bromantane is that we know relatively little about them. There is a lack of high-quality research, especially in healthy humans.

Because of the lack of research on Bromantane, we never recommend that people use it.

If you have already decided to use it, here are some guidelines to maximize the benefits and minimize the risks.

How much and how often should you dose Bromantane?

In studies in humans, Bromantane is usually given to participants in doses between 50 and 100mg. [6]

It is usually taken daily. [7]

What time of day should you take Bromantane?

Bromantane is known to promote wakefulness and alertness. It is a psychostimulant, which entails it will be hard for you to fall asleep if you take Bromantane late in the evening. [1]

How does Bromantane work in the brain?

The neuropsychopharmacological effects of Bromantane have not yet fully been discovered by researchers.

Here are some of the mechanisms which researchers have explored and found involved in the effects of the drug on mood and cognition:

• Increased the release of dopamine potently and for a long period (in rat striatum) [15]
• Increased middle-frequency alpha-rhythm power and lowered delta- and beta1-band power (in healthy humans) [3]
• Decreased total and absolute powers of all frequency bands of EEG spectra, and changed structural spectra in the cortex and in the hippocampus (in rats) [17]
• Decreased the relative power of theta-band and increased the relative power of beta 1, 2-activity (in rats) [18]
• Exerts dopaminergic and serotonergic activity (in rat brains, including in the frontal cortex and cerebellum) [19][20]
• Reduced inflammation (IL-6, IL-17, and IL-4 in the blood of mice) [21]
• Reduced the dopamine metabolites homovanillic acids and 3,4-dioxyphenylacetic (in rat striatum) [22]
• "Bromantane strengthens GABA-ergic mediation, reducing gene expression, supervising synthesis of GABA-transporters, and functioning as a return capture mediator." [2]

How long does it take for Bromantane to reach peak concentrations in the blood?

The time it takes for Bromantane to reach maximum concentrations in the human plasma is around 3h in women and 4h in men. [23]

How does it feel when you take Bromantane?

The following qualitative user experience reports and reviews are included to give you an understanding of what the experience of taking Bromantane is like.

Anecdotal Bromantane experience reports and reviews from Reddit

One person reported the following:

"So far I’ve taken it 3 times. First time was about 60mg I believe, took it orally and didn’t notice anything. Next two times I tried it sublingually at about 20mg and I think I noticed a slight increase in mental energy but not much of a mood enhancement, in fact I ended up being in a pretty bad mood both times but that could be placebo." [26]

Another user said they had the following effects from Bromantane:

"I called Ladasten "the Real Modafinil" in that it kept me awake all night - (but in a very stress-free, natural way - unlike an irritable stim or caffeine). I'm just started trying much smaller amounts sublingual now. It seems to keep me going all day, and go to bed later. Can't say it's a huge mood boost - just a little less anxiety and fatigue." [31]

Several people said Bromantane resulted in them being awake for longer in the evening. [32]

Another redditor said they had the following experiences after 3 days of Bromantane use:

"Happy to do my work and not overwhelmed by the massive amount of work I have (I run 2 businesses and am in the process of launching another). Everything just seems to fall into place, and my depression is gone. I honestly have not felt this was since the first time I tried Wellbutrin (which after the first time never felt good again and I stopped taking it).

This is by far the best nootropic I have ever come across and I will be continuing to take it." [33]

This user said that, in their experience, Bromantane was better than [Modafinil] and [Piracetam]. [34]

Finally, one redditor said that "It really helps you get things done and decreases anxiety ... both socially and in general ..." [35]

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