Donepezil
Other names Aricept
Benefits
Read about the effects of Donepezil in relation to the amount of evidence we've found
Risks
The legality and side effects of Donepezil
You should always consider the risks of a nootropic before you use it.
Side effects
No negative side effects were seen in any of the studies that we reviewed.
Interactions
Supplements and drugs can interact with Donepezil to increase or decrease the positive or negative effects you experience. If you are already using any supplements or drugs, speak with your trusted medical professional before you experiment with Donepezil. To learn more about the potential interactions between Donepezil and other substances, use interaction-checker.
Legality
Is your country not included? Learn how to find out if Donepezil is legal in your country.
Legality Disclaimer
The contents herein are not legal advice or a substitute for legal counsel. information is not intended to create, and receipt of it does not constitute, an attorney-client relationship. While we have done our best to be as accurate as possible in the information we convey to you about the legality of nootropics, there is a risk for inaccuracies and errors. If you’re uncertain about the legality of any of your actions, contact a legal counsel or your local authorities governing the legality of various substances you may want to use/import/travel with.
FAQ
Frequently asked questions about Donepezil
What substances may stack well with donepezil?
An acetylcholinesterase inhibitor is a drug that reduces the activity of the enzyme acetylcholinesterase in the brain. This enzyme is responsible for the breakdown of acetylcholine in the brain. The inhibition of acetylcholinesterase through the use of an acetylcholinesterase inhibitor will likely result in higher brain acetylcholine levels, perhaps especially if there is an abundant supply of choline to the brain.
Donepezil is an acetylcholinesterase inhibitor.
The combination of Alpha-GPC and an acetylcholinesterase inhibitor enhances cholinergic neurotransmission more than either of the two alone, suggests two animal studies. [13][14] It has also been found that the combination of donepezil and Alpha-GPC resulted in prolonged cognitive benefits in people with brain injury. [15]
Before combining any drugs or supplements, talk with your trusted medical professional about the risks involved.
Who should use Donepezil?
There’s a need for more high-quality scientific information about the safety and effectiveness of Donepezil. Specifically, there’s a great degree of individual variance in how people respond to nootropics in general and Donepezil in particular. This means that if you use Donepezil, you may not experience the same effects as those that were seen in scientific studies on it.
It is currently largely unknown what factors play a role in whether a nootropic will be effective for a person.
While we wait for science to explain who is likely to respond to which nootropics, patient self-experimentation with nootropics that have been found safe and effective in placebo-controlled studies in healthy humans is a proven strategy to feel and perform better with the help of nootropics.
Studies
Studies conducted on the effects of Donepezil in healthy humans
In the 2 studies that met our inclusion criteria, 15 participants received Donepezil. In total, we examined 10 studies on the effects Donepezil, which you can find summaries of below.
Summary
"The placebo group fared approximately 0.5 second better in reaction time to wind gusts and showed a nonsignificant tendency toward less deviation of road position, compared with the donepezil group."
This study is used in our recommendation engine calculations. Learn more about how we select studies
Summary
"There was a significant decrease in inspection time in the donepezil condition compared to the placebo condition ..."
Study groups
Adults using 5 Milligram
This study is used in our recommendation engine calculations. Learn more about how we select studies
Summary
"The findings suggest that accurately increasing acetylcholine levels and cholinergic function with donepezil has no behavioral pharmacodynamic effects on aspects of attention, visual-conceptual and visual-motor tracking, motor speed and agility, and working memory in healthy normal Ss."
Study groups
Adults using 5 Milligram
Summary
"... demonstrated significant drug effects that were specific to episodic memory in both the verbal and visual domain. Additionally, donezepil significantly improved long-term visual episodic recall."
Summary
"AChEIs, such as donepezil, may have pro-cognitive effects among healthy smokers while they continue to smoke as usual."
Summary
"There were no differences in performance between the placebo and the no treatment arms. However, on day 21, subjects in the donepezil group performed slightly but significantly worse on some tests of speed, attention and memory (p < 0.05) compared to the pooled control group (placebo and no treatment arms). No improvement in performance was present while on donepezil at days 21 or 28. While the results are counter to expectations, some tests in the battery did detect a cognitive change (transient mild worsening during drug administration) in healthy volunteers."
Summary
"AChEIs, such as donepezil, may have pro-cognitive effects among healthy smokers while they continue to smoke as usual."
Summary
Donepezil improved reaction time performance.
Summary
"Positive cognitive effects of acute donepezil can be observed in various cognitive domains including mood, but its full nootropic potential is more clearly found close to theoretical peak-plasma concentration."
Summary
"Donepezil significantly increased ratings of vigour and anxiety symptoms (medium effect sizes)."
Last updated Saturday, June 10, 2023