Fladrafinil

Other names CRL-40,941, Fluorafinil

Fladrafinil is a eugeroic, just like Modafinil, which means it promotes wakefulness (though the actual efficacy of Fladrafinil for this purpose is unknown in humans). Modafinil is one of the most widely used cognitive enhancers in the world. People tend to use Fladrafinil because it allegedly improves energy more. Does evidence suggest Fladrafinil is just as safe and effective as Modafinil? Read on to find out what the science says about its risks and benefits.

This nootropic has no healthy human placebo-controlled studies that meet our inclusion criteria. Negative side effects can occur if used carelessly, so make sure you’re aware of the risks of Fladrafinil.

Buy Fladrafinil

Benefits

Read about the effects of Fladrafinil in relation to the amount of evidence we've found

Why do people use Fladrafinil?

People who self-experiment with Fladrafinil often state they use it to improve their:

Let's see what the science available says about the efficacy of Fladrafinil for the purposes of enhancement of the above-mentioned aspects of mood and cognition in healthy humans.

Fladrafinil for improved memory, focus, mood, and energy

No published studies have examined the effects of Fladrafinil in humans or in any animal.

Why would people believe that Fladrafinil might be an effective enhancer of memory, focus, mood, and energy if there is no scientific evidence to suggest that it is effective for these purposes?

Most nootropics have at least some animal studies on their cognitive effects published online, but Fladrafinil doesn't even have that.

The reason for people's interest in Fladrafinil is very likely that it is similar to Modafinil.

Modafinil is one of the most widely used, and most widely studied nootropics in the world.

A lot of studies have found that Modafinil effectively enhances several aspects of cognition and mood in healthy humans, including memory, focus, motivation, and vigilance. [7][8][9][10][11][12]

But whether Fladrafinil has similar cognitive benefits is not known to science.

Fun fact: Many blogs state online that Fladrafinil can lead to anti-aggressive effects in animals and in humans, but no studies have been published online suggesting such effects.

The best source of evidence that exists on the effects of Fladrafinil is anecdotal user experience reports.

Remember that anecdotal evidence is generally of low quality, so be very careful not to interpret any of these as good sources of scientific information that convey purely the real effects of Fladrafinil.

Fladrafinil reviews from people who reported they used it

One person reported there was no subjective difference between Adrafinil and Fladrafinil. [15]

Another person reported that while several other nootropics including Adrafinil had no effect for them, Fladrafinil did have strong beneficial effects. [16]

One person reported that they got "lame" effects from one Fladrafinil product, but had an entirely different and positive experience with another fladrafinil product. This suggests that it is very important to buy fladrafinil from a trusted source such as Science.bio that provides certificates of analysis for their products verifying the chemical purity and quality. Otherwise, you might get something entirely different that could be ineffective or possibly even dangerous. The user in question had the following effects from 50mg of the "good" Fladrafinil product:

"Soon after a dose I would feel very aware of my surroundings, had good reaction time, and my brain just felt wide awake, but not uncomfortably so. The anti-aggressive effects that were noted in literature I think were valid. I know a lot of people thought it was a dud as that was not noticeable to anyone, but after a long time taking it daily, this effect was noticeable. Especially when I didn't take it, I could see a huge difference, and this was replicated many times. It's not at all a "Serenic" which I believe was the majority interpretation of "anti-agressive" including myself, but it was completely different. The best way I could describe it is the difference between not getting enough sleep for many days, vs. getting proper sleep. I'm usually on the road by 8AM and people out here drive like idiots, so fricken scary the shit that people pull. Normally I get really pissed off having to navigate multiple accidents every morning for just a 4 mile drive, but interestingly I wasn't as bothered by this when I had Fladrafinil."

Another redditor reported the laziness-reducing effects from 75mg fladrafinil daily. [18]

Yet another person on reddit said the effects were not as strong as they had expected and that they would not recommend it to anyone. [19]

Risks

The legality and side effects of Fladrafinil

FAQ

Frequently asked questions about Fladrafinil

Should you use Fladrafinil?

One thing that is certain about the effects of Fladrafinil is that we know relatively little about them. There is a lack of high-quality research, especially in healthy humans.

Because of the lack of research on Fladrafinil, we never recommend that people use it.

If you have already decided to use it, here are some guidelines to maximize the benefits and minimize the risks.

How much and how often should you dose Fladrafinil?

No human studies have examined the safety or efficacy of any dose of Fladrafinil.

According to the anecdotes we have found, the use of 40-80mg Fladrafinil has resulted in benefits for some people.

What time of day should you take Fladrafinil?

If you are going to take Fladrafinil, take it in the morning as early as possible after wake-up to minimize any potential negative effects on sleep, considering its stimulatory effects.

What substances may stack well with Fladrafinil?

There's no high-quality research on the effects of combining Fladrafinil with other substances, such as nootropic drugs or supplements. The safety and efficacy of the below-listed combinations are supported only by anecdotal reports.

People tend to report better effects from Fladrafinil when they also use:

Choline sources, such as Alpha-GPC, Choline Bitartrate, or CDP- Choline
L-Theanine
Bacopa Monnieri

Before combining any drugs or supplements, talk with your trusted medical professional about the risks involved.

How does Fladrafinil work?

The mechanisms of action of Fladrafinil have not been researched in any published scientific studies.

It is likely that Fladrafinil shares many mechanisms of action with Modafinil.

How fast does Fladrafinil reach peak concentrations in the blood and how long is its half-life?

The pharmacokinetic profile (how a drug moves throughout the body) of Fladrafinil has not been researched in any published scientific studies.

Modafinil has the following pharmacokinetic profile:

"After single or multiple oral doses, modafinil is readily absorbed, reaching maximum plasma concentrations at 2-4 hours after administration and pharmacokinetic steady state within 2-4 days. Its pharmacokinetics are dose-independent between 200 and 600 mg/day. The elimination half-life is approximately 12-15 hours ..." [26]

A user reported that they experienced the following effects from fladrafinil:

"onset of fladrafinil for me is about 1 hour with heavy onset at 2 and lasts about 8+ hours. I have no unpleasant feelings and it helps my sleep schedule massively, no more 'insomnia'"

What other "afinils" do people use as cognitive enhancers?

Other "afinils" that some people use for their possible cognitive benefits include:

Modafinil
Adrafinil
Flmodafinil
Hydrafinil
Armodafinil

What is the chemical formula for Fladrafinil?

According to PubChem [29], the chemical molecular formula for Fladrafinil is C₁₅H₁₃F₂NO₃S and the structural formula is: Source: PubChem

How does Fladrafinil differ from Modafinil chemically?

Fladrafinil is heavier per molecule (and per mol) than Modafinil. Modafinil has a molecular weight of 273.4g/mol whereas the mass of Fladrafinil is 325g.3/mol. [30][31]

The chemical structure of Fladrafinil is very similar to that of Modafinil. There are only three differences between the molecules structurally.

There is one fluorine atom attached two one of the carbon atoms for both of the benzene rings in Fladrafinil and not in Modafinil
There is a hydroxyl (-OH) group instead of one of the hydrogen atoms bonded to the nitrogen atom in Fladrafinil compared with Modafinil

So the chemical structure of Fladrafinil compared with Modafinil is as follows: vs:

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Studies

Studies conducted on the effects of Fladrafinil in healthy humans

Last updated Saturday, June 10, 2023