Methylliberine

Methylliberine Negative Side Effects

There has been more research on the safety of Methylliberine than on the benefits of it.

There's one placebo-controlled study on the safety of Methylliberine. It is named "Safety of Short-Term Supplementation with Methylliberine (Dynamine ®) Alone and in Combination with TeaCrine ® in Young Adults" and was published in February 2020. [3]

The study only examined the potential health risks of Methylliberine on cardiovascular function.

A total of 100 participants received 100-150mg of Methylliberine for four weeks with or without Theacrine. No adverse effects were reported for any study group.

Based on the data that is available, Methylliberine appears safe, but the reality is that we are lacking the studies necessary to make any definitive claims regarding the long-term safety of Methylliberine.

How does Methylliberine affect Blood Pressure and Heart Rate?

There have been several studies on the cardiovascular effects of Methylliberine, all with positive results.

In contrast with Caffeine, the preliminary evidence available suggests Methylliberine has no negative cardiovascular health effects. [4][[1]][6]

How does it feel when you take Methylliberine?

The following qualitative user experience reports and reviews are included to give you an understanding of what the experience of taking Methylliberine is like.

One user reported the following:

"Within the first 25 minutes, I was dialed in. The type of dialed in where you go to the gym, kill your workout. Then go home, do all of you laundry, clean the house and start working on projects you have been putting off kind of dialed in. It was great. Energy and mood were on point. It lasted for about three hours but you don’t realize it has tapered off. You just keep going on momentum." [2]

Another person said they had slightly better focus, felt more in tune with what was going on, and that they liked it. [8]

Is Methylliberine found in food?

Methylliberine is primarily found in Kucha tea leaves [9] but also in coffee beans, tea, cola nuts, guarana, cocoa, and yerba maté. [13]

Should you use Methylliberine?

There's very little research on the effects of Methylliberine in healthy humans. For most people, Caffeine is likely a better alternative, considering it has been studied so much more.

Is Methylliberine a good Caffeine alternative?

If research is published in the coming years to support the long term safety of Methylliberine, it is likely a good substance to experiment with for people who want better energy, mood, and focus without the negative side effects of Caffeine.

How much and how often should you dose methylliberine?

Between 25 and 150mg is the doses that have been used in studies in humans and are seem safe for short term use.

This is the dose-range that people who review it online tend to use as well.

How long do the effects of Methylliberine last?

There appears to be a consensus amongst people who've reported on their experiences with it online that the effects come very quickly when you take it, and that they last for about 3 hours.

There has been no scientific study published that examined the duration of effects or half-life of Methylliberine.

What time of day should you use Methylliberine?

Due to its stimulant effects, you should likely avoid it just prior to sleep.

Compared with Caffeine, Methylliberine is likely going to have a shorter duration of effects.

You might want to experiment with your time of dosing to find how short prior to sleep you can take Methylliberine without experiencing negative side effects.

What substances stack well with Methylliberine?

There's no high-quality research on the benefits of combining Methylliberine with other substances, such as nootropic drugs or supplements. The efficacy of the below-listed combinations are supported only by anecdotal reports.

People tend to report better effects from Methylliberine when they also use:

• Caffeine
• Theacrine

A combination of Methylliberine, Caffeine, and Theacrine has also been described as having synergistic effects by some users.

The combination of these three stimulant nootropics or Methylliberine with either Caffeine or Theacrine appears safe in healthy humans when used in appropriate doses once. [1]

Studies on long-term use of Caffeine, Theacrine, and Methylliberine combined have not been conducted.

There has been one study on the safety of combining Theacrine (25-50 mg) with Methylliberine (100-150mg). No adverse events were reported in that study.

According to the company that moves the science of Methylliberine forward, an unpublished study supposedly found that Methylliberine combined with Caffeine or Caffeine and Theacrine increased the amount of time that Caffeine stayed in the systems of the participants.

Source: Compound Solutions

While this drug interaction effect can be interpreted as positive, it may be negative in that it appears to slow down the body's elimination of Caffeine. We don't know what the downstream effects of this are, especially not if used as a dosing strategy every day for the long term.

Before combining any drugs or supplements, talk with your trusted medical professional about the risks involved.

Will you build a tolerance to Methylliberine?

The research necessary to answer this question has not been conducted yet.

Anecdotal reports suggest that there's little, but some, build-up of tolerance after daily use for several weeks.

Have other questions that would fit well on this Methylliberine wiki page? Email us.