St. John's Wort

Other names Hypericum Perforatum, Hypericum Perforatum L., Perforate St John's-wort, Saint John's Wort

This nootropic has no healthy human placebo-controlled studies that meet our inclusion criteria. Negative side effects can occur if used carelessly, so make sure you’re aware of the risks of St. John's Wort.

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Risks

The legality and side effects of St. John's Wort

You should always consider the risks of a nootropic before you use it.

Side effects

Interactions

Supplements and drugs can interact with St. John's Wort to increase or decrease the positive or negative effects you experience. If you are already using any supplements or drugs, speak with your trusted medical professional before you experiment with St. John's Wort. To learn more about the potential interactions between St. John's Wort and other substances, use interaction-checker.

Legality

Is your country not included? Learn how to find out if St. John's Wort is legal in your country.

Legality Disclaimer

The contents herein are not legal advice or a substitute for legal counsel. information is not intended to create, and receipt of it does not constitute, an attorney-client relationship. While we have done our best to be as accurate as possible in the information we convey to you about the legality of nootropics, there is a risk for inaccuracies and errors. If you’re uncertain about the legality of any of your actions, contact a legal counsel or your local authorities governing the legality of various substances you may want to use/import/travel with.

Studies

Studies conducted on the effects of St. John's Wort in healthy humans

No placebo-controlled trials on healthy humans that meet our inclusion criteria have been conducted on St. John's Wort.

An Investigation Into the Acute Nootropic Effects of Hypericum Perforatum L. (St. John's Wort) in Healthy Human Volunteers

placebo-controlled

Summary

"The findings suggested that hypericum does not have an acute nootropic effect in healthy humans at these doses. However, there was some evidence for an impairing effect on accuracy of numeric working memory and delayed picture recognition at the higher dose."

A Preliminary Investigation on the Acute Pharmacodynamic Effects of Hypericum on Cognitive and Psychomotor Performance

placebo-controlled

Summary

"Current findings suggest that clinical doses of hypericum do not impair attention, sensorimotor function or information processing."

The acute effect of Hypericum perforatum on short-term memory in healthy adults

placebo-controlled

Summary

"The results indicate that acute treatment with small (250 mg) dosages of H. perforatum has a positive effect on the capacity of short-term verbal memory, and stress the importance of maintaining small dosages in nootropic applications."

Last updated Saturday, June 10, 2023