Trimethylglycine

Other names Betaine, Glycine Betaine

Browser our suppliers for Trimethylglycine

Benefits

Read about the effects of Trimethylglycine in relation to the amount of evidence we've found

We analyzed data from 3 placebo-controlled studies on the effects of Trimethylglycine in healthy humans and summarized the results here:

Effect	Effect size	Evidence amount
Stress	Minute positive	Small
Mood	Minute positive	Preliminary
Energy	Minute positive	Relatively large

Risks

The legality and side effects of Trimethylglycine

You should always consider the risks of a nootropic before you use it.

Side effects

No negative side effects were seen in any of the studies that we reviewed.

Interactions

Supplements and drugs can interact with Trimethylglycine to increase or decrease the positive or negative effects you experience. If you are already using any supplements or drugs, speak with your trusted medical professional before you experiment with Trimethylglycine. To learn more about the potential interactions between Trimethylglycine and other substances, use interaction-checker.

Legality

Is your country not included? Learn how to find out if Trimethylglycine is legal in your country.

Legality Disclaimer

The contents herein are not legal advice or a substitute for legal counsel. information is not intended to create, and receipt of it does not constitute, an attorney-client relationship. While we have done our best to be as accurate as possible in the information we convey to you about the legality of nootropics, there is a risk for inaccuracies and errors. If you’re uncertain about the legality of any of your actions, contact a legal counsel or your local authorities governing the legality of various substances you may want to use/import/travel with.

How To Use

Dose, frequency and duration

It is usually safer and more effective to use nootropics as they have been used in studies on humans. In the only study that we’ve reviewed, Trimethylglycine was used in the following ways:

1250 Milligram doses for acute effects
[2]
2500 Milligram doses for acute effects
[1]
2500 Milligram doses for acute effects
[3]

Studies

Studies conducted on the effects of Trimethylglycine in healthy humans

In the 3 studies that met our inclusion criteria, 36 participants received Trimethylglycine. In total, we examined 4 studies on the effects Trimethylglycine, which you can find summaries of below.

Effect of 15 Days of Betaine Ingestion on Concentric and Eccentric Force Outputs During Isokinetic Exercise

placebo-controlled

crossover

This study is used in our recommendation engine calculations. Learn more about how we select studies

Summary

15 days of betaine supplementation did not increase peak force outputs but did appear to reduce subjective measures of fatigue to the exercise protocol

Study groups

Adults using 2500 Milligram

Effect of betaine supplementation on power performance and fatigue

placebo-controlled

This study is used in our recommendation engine calculations. Learn more about how we select studies

Summary

Two-weeks of betaine supplementation in active, college males appeared to improve muscle endurance of the squat exercise, and increase the quality of repetitions performed.

Study groups

Adults using 1250 Milligram

The Effects of Chronic Betaine Supplementation on Exercise Performance, Skeletal Muscle Oxygen Saturation and Associated Biochemical Parameters in Resistance Trained Men

placebo-controlled

crossover

This study is used in our recommendation engine calculations. Learn more about how we select studies

Summary

This data indicates that betaine supplementation at 2.5 g·d for 14 days has little to no effect on muscular force and power production, while it may improve performance in activities that emphasize muscular endurance.

Study groups

Adults using 2500 Milligram

Effects of Betaine Supplementation on Muscle Strength and Power: A Systematic Review

systematic review

Summary

"Only 2 of the studies reported increases in strength or power after supplementation with BET. The remaining 5 studies showed no change in any strength or power outcome measures with BET supplementation. This review highlights the lack of evidence for a clear ergogenic effect of BET supplementation on strength and power performance."

Last updated Saturday, June 10, 2023